Endocrine Abstracts

Introduction: The European Society of Endocrinology Clinical Practice Guideline defines follow-up recommendations for AI based on the 1 mg overnight dexamethasone suppression test and the presence of associated comorbidities. Follow-up is not recommended for AI presenting serum cortisol levels post dexamethasone ≤1.8 μg/dl neither those presenting serum cortisol levels post dexamethasone between 1.9–5 μg/dl (defined as ‘possible autonomous cortisol se...

Introduction: A two-step approach is usually used to diagnose GDM. At 24–28 weeks of pregnancy, a 50 g 1-hour glucose or O’Sullivan test is performed. If it is positive (≥140 mg/dl), it is followed by a 100 g-3 hours-Oral Glucose Tolerance Test (OGTT) which is considered positive if at least two or more values are ≥ of reference values (105-190-165-145 mg/dl). Despite it is not include in any clinical practice guideline, sometimes the 100 g OGTT is obviat...

Background: The main limitation of fine-needle aspiration (FNA) is represented by indeterminate category (Bethesda III and IV) in which the risk of malignancy is between 5-30%. Given this result, surgical treatment is necessary in many cases. The aim of our study is to assess whether the ultrasound patterns proposed by the ATA, help us to stratify the risk of malignancy in nodules with Bethesda IV cytology result.Methods: From January 2011 to June 2017 w...

Objective: To evaluate the impact of a decision support system (DSS) based on artificial intelligence (AI) -KoiosDS- on ultrasound (US) image analysis and risk stratification in thyroid nodules.Material and methods: Retrospective US study of all thyroid nodules with histologic (AP) result from June 2020 to December 2021. Diagnostic performance of US with ACR-TIRADS, by six endocrinologists and DSS, before and after the use of AI was evaluated.<p clas...

Growth hormone deficiency (GHD) diagnosis poses a significant challenge since no test definitively diagnoses GHD. The current diagnostic approach for GHD relies on a determination of auxologic parameters followed by determining Growth Hormone (GH) levels and Insulin-like Growth Factor-I (IGF-I) in serum. However, clinical assessment and interpretation of GH and IGF-1 levels lack sensitivity. Further provocative studies of GH secretion do not have a precise cutoff level that di...

Objective: 6% of people with diabetes present with diabetic foot as a complication, which means greater morbidity and mortality compared to those who do not. Its diagnosis and management by multidisciplinary teams including surgeons can improve these patients’ care. The objective was to analyze the main characteristics of patients and health results obtained, as well as to evaluate the impact of PAD (peripheral artery disease) existence in patients cared for in our multid...

Adrenocortical carcinoma (ACC) is a rare endocrine malignancy. ACC may rarely occur as part of familial cancer syndromes, but the majority of the cases occur sporadically. A significant proportion of sporadic ACC cases may be preceded by other malignancies and adrenal metastasis from these primary tumours may frequently occur. Herein we present three cases where sporadic ACC was identified in patients with coexistent or previous history of melanoma.Case ...

Introduction: Zinc transporter 8 (ZnT8) autoimmunity has been established as one of the markers for the diagnosis of type 1 diabetes (T1D) along with glutamate decarboxylase (GAD) and tyrosine phosphatase IA-2 (IA-2) antibodies. The aim of this study is to understand the status of pancreatic autoimmunity in the diagnosis of T1D, with special attention to the usefulness of ZnT8. In addition, as a second objective, we study the proposal to perform the assessment of pancreatic au...

Background: Acute intermittent porphyria (AIP) is an inherited autosomal dominant disorder characterized by hepatic deficiency of hydroxymethylbilane synthase (HMBS)/porphobilinogen deaminase (PBGD), the third enzyme of the heme synthesis pathway. Hyponatremia is one of the main presenting symptoms and it is thought to be related to an inadequate secretion of ADH (SIADH). Since AIP is an uncommon disease, there is little information about how AIP related hyponatremia responds ...

Background: Muscle weakness may persist in patients with Cushing’s syndrome (CS) long-term after resolution of hypercortisolism, but mechanisms determining this sustained impairment are not known. We hypothesized that alteration of muscle structure, due to fatty infiltration, is associated with muscle dysfunctions in these patients.Patients & methods: Twenty-six CS women [mean(±S.D.) age 49±12 years; mean(±S....